GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
THCA | cis | rs16958440 | 1 | rs62096474 | chr18:44647504 | PIAS2 | chr18:44392061-44500123:- | -0.15 | -3.37 | 0.000804 | Sitting height ratio |
THCA | cis | rs16958440 | 1 | rs62096476 | chr18:44658621 | HDHD2 | chr18:44633782-44676871:- | 0.26 | 4.94 | 1.1E-6 | Sitting height ratio |
THCA | cis | rs16958440 | 1 | rs62096476 | chr18:44658621 | PIAS2 | chr18:44392061-44500123:- | -0.16 | -3.5 | 0.000508 | Sitting height ratio |
THCA | cis | rs16958440 | 1 | rs62096478 | chr18:44662409 | HDHD2 | chr18:44633782-44676871:- | 0.26 | 4.94 | 1.1E-6 | Sitting height ratio |
THCA | cis | rs16958440 | 1 | rs62096478 | chr18:44662409 | PIAS2 | chr18:44392061-44500123:- | -0.16 | -3.5 | 0.000508 | Sitting height ratio |
THCA | cis | rs11874381 | 1 | rs62101780 | chr18:47211344 | CXXC1 | chr18:47808715-47814692:- | -0.09 | -3.54 | 0.000444 | C-reactive protein levels or HDL-cholesterol levels (pleiotropy) |
THCA | cis | rs11874381 | 1 | rs62101781 | chr18:47211860 | CXXC1 | chr18:47808715-47814692:- | -0.1 | -3.62 | 0.000324 | C-reactive protein levels or HDL-cholesterol levels (pleiotropy) |
THCA | cis | rs62103177 | 1 | rs62103177 | chr18:77624479 | HSBP1L1 | chr18:77724582-77730820:+ | 0.17 | 3.39 | 0.000746 | Opioid sensitivity |
THCA | cis | rs62103177 | 1 | rs62103177 | chr18:77624479 | TXNL4A | chr18:77732869-77793915:- | 0.15 | 4.26 | 2.49E-5 | Opioid sensitivity |
THCA | cis | rs2108622 | 1 | rs62107762 | chr19:15982538 | CYP4F11 | chr19:16023180-16045676:- | -0.24 | -3.71 | 0.000236 | Acenocoumarol maintenance dosage;Vitamin E levels;Circulating phylloquinone levels;Metabolite levels;Response to Vitamin E supplementation;Warfarin maintenance dose |
THCA | cis | rs8105895 | 1 | rs62112917 | chr19:22226580 | ZNF492 | chr19:22817126-22850472:+ | 0.25 | 3.36 | 0.000854 | Body mass index (change over time) |
THCA | cis | rs2005199 | 1 | rs62113284 | chr19:52031926 | ZNF175 | chr19:52074531-52092990:+ | -0.32 | -3.85 | 0.000132 | Carotid intima media thickness |
THCA | cis | rs60843830 | 1 | rs62114497 | chr2:214837 | SH3YL1 | chr2:218138-264810:- | -0.91 | -24.48 | 2.28E-86 | Spherical equivalent (joint main effects and education interaction) |
THCA | cis | rs60843830 | 1 | rs62114501 | chr2:231741 | SH3YL1 | chr2:218138-264810:- | -0.95 | -26.63 | 1.87E-96 | Spherical equivalent (joint main effects and education interaction) |
THCA | cis | rs60843830 | 1 | rs62114505 | chr2:242426 | SH3YL1 | chr2:218138-264810:- | -0.96 | -26.75 | 5.11E-97 | Spherical equivalent (joint main effects and education interaction) |